Selectfluor™
Other names: 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), F-TEDA
[C7H14ClFN2][BF4]2
3/50 
common
Selectfluor™ is a powerful electrophilic fluorinating agent derived from DABCO (and a trademark of Air Products and Chemicals, Inc.). Unlike its parent compound, which is a neutral base, Selectfluor™ features a positively charged diazoniabicyclo[2.2.2]octane core, making it highly reactive toward nucleophiles. First introduced in the 1990s, Selectfluor™ revolutionized the field of selective fluorination, enabling the direct transfer of fluorine to a wide range of organic substrates under comparatively mild conditions. This has made it an essential tool in pharmaceutical and agrochemical synthesis, where fluorinated compounds often exhibit enhanced metabolic stability and bioactivity. In its pure form, Selectfluor™ appears as a white crystalline solid, readily soluble in polar solvents. Its combination of high reactivity and ease of use underpins its ubiquity in modern synthetic fluorine chemistry.