Hoveyda-Grubbs Gen1

Other names: first-generation Hoveyda-Grubbs catalyst, di­chloro(o-iso­prop­oxy­phenyl­methyl­ene)(tri­cyclo­hexyl­phosphine)ruthenium(II)

C₂₈H₄₅Cl₂OPRu

11/50 common

The first-generation Hoveyda-Grubbs catalyst is a ruthenium-based complex that enhanced olefin metathesis by incorporating a chelating benzylidene ligand, improving stability and catalyst turnover. Its structure features a ruthenium center coordinated to a benzylidene ligand with an o-isopropoxyphenyl substituent, a tricyclohexylphosphine (PCy₃) ligand, and two chloride ligands. This modification slows catalyst decomposition while maintaining high reactivity. In its pure form, Hoveyda-Grubbs Gen1 appears as a ruddy brown crystalline powder.